SIGLEC1 / CD169 / Sialoadhesin Antibody from BIORBYT LTD.
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| Antigenic Specificity | SIGLEC1 / CD169 / Sialoadhesin |
| Clone | HSn 7D2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | FACS, IF, IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1,709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. |
| Immunogen | An Fc fusion protein containing N-terminal 4 domains of human sialoadhesin was used as the immunogen for this SIGLEC1 antibody. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | orb639927 |
| Price | $405 |
| Order / More Info | SIGLEC1 / CD169 / Sialoadhesin Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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