GAD67 Antibody from BIORBYT LTD.

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Antigenic SpecificityGAD67
CloneGAD1/2563
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b, kappa
FormatProtein G purified
Size100 ug, 20 ug
Concentrationn/a
ApplicationsELISA, FACS, WB
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DescriptionThis mAb recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1). GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
ImmunogenA portion of amino acids 72-135 from the human protein were used as the immunogen for this GAD67 antibody.
Other Namesn/a
Gene, Accession #UniProt: Q99259
Catalog #orb606600
Price$764
Order / More InfoGAD67 Antibody from BIORBYT LTD.
Product Specific Referencesn/a
BIORBYT LTD.
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240

info@biorbyt.com

http://www.biorbyt.com

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St Louis, MO 63132
Email: info@biorbyt.com
Phone: +1 (415) 906-5211
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