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Antigenic Specificity | CARM1 / PRMT4 |
Clone | CARM1/7426 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CARM1 (coactivator-associated arginine methyltransferase 1), also known as protein arginine N-methyltransferase 4 (PRMT4), is a 585 amino acid nuclear and cytoplasmic protein belonging to the protein arginine N-methyltransferase family. As a protein arginine N-methyltransferase, CARM1 is capable of catalyzing the transfer of methyl groups from S-adenosylmethionine to the guanidino group nitrogen atoms of arginine residues in certain proteins involved in mRNA stability, DNA packaging and transcriptional regulation. The methyltransferase activity of CARM1 has been found to be negatively regulated through phosphorylation at a conserved serine residue. CARM1 acts as a positive regulator for multiple transcription factors and functions as a secondary coactivator through its association with p160 coactivators. CARM1 exists as two alternatively spliced isoforms, and is encoded by a gene that maps to human chromosome 19p13.2. |
Immunogen | A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the CARM1 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: Q86X55 |
Catalog # | orb1824844 |
Price | $764 |
Order / More Info | CARM1 / PRMT4 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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