PRDM1 / BLIMP1 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | PRDM1 / BLIMP1 |
| Clone | PCRP-PRDM1-2B9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | FACS, IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated. |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the BLIMP-1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: O75626 |
| Catalog # | orb1823083 |
| Price | $764 |
| Order / More Info | PRDM1 / BLIMP1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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