Retinoblastoma / Rb1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Retinoblastoma / Rb1 |
| Clone | rRB1/8060 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma. |
| Immunogen | A recombinant human protein fragment of 283 amino acids was used as the immunogen for the recombinant Rb1 antibody. Its epitope is localized between amino acids 703-772. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P06400 |
| Catalog # | orb1825605 |
| Price | $405 |
| Order / More Info | Retinoblastoma / Rb1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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