TIM-3 / HAVCR2 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-TIM-3 / HAVCR2 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | TIM-3 / HAVCR2 |
| Clone | TIM3/6863R |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+ Tc1) but not on helper T cells (CD4+ Th2 and CD8+ Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation. |
| Immunogen | A recombinant fragment of human TIM3 protein (within amino acids 1-200) was used as the immunogen for the TIM-3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q8TDQ0 |
| Catalog # | orb1823275 |
| Price | $764 |
| Order / More Info | TIM-3 / HAVCR2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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