IL-1 Receptor Antagonist Antibody from BIORBYT LTD.
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| Antigenic Specificity | IL-1 Receptor Antagonist |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | DEAE purified |
| Size | 25 ul |
| Concentration | 1 mg/mL |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This is an IgG preparation of whole rabbit serum purified by DEAE chromatography. In general, this antibody also detects primate IL-1Ra in the same formats using similar dilutions, but not mouse or rabbit IL-1Ra. The antibody does not recognize human IL-1a, IL-1b or IL-1 receptor type I and type II. This antibody is primarily directed against the secreted form of IL-1Ra (also termed sIL-1Ra) but recognizes the native (non-denatured) as well as denatured intracellular form of IL-1Ra (also termed icIL-1Ra). IcIL-1Ra is found in many cells as constitutively expressed protein, particularly epithelial cells and keratinocytes. This antibody does not distinguish between sIL-1Ra and icIL-1Ra in ELISA formats or by immunohistochemistry. When used in immunoblot analysis, it will recognize 17,000 MW IL-1Ra in supernatants released from supernatants or lysates of 2 x 106 endotoxin-stimulated human peripheral blood mononuclear cells (PBMC). PBMC are stimulated for 24 hours with 1% (v/v) human serum plus 10 ng/mL E.coli LPS. However, in lysates of PBMC, icIL-1Ra is also found after 48-72 hours of culture. In monocytic cells, the initial IL-1Ra transcript is for sIL-1Ra which can be found almost exclusively intracellularly. |
| Immunogen | The whole rabbit serum used to produce this IgG fraction antibody was prepared by repeated immunizations with recombinant human sIL-1Ra produced in E.coli. |
| Other Names | IL1RA, IL1RN, IL1RT1, Interleukin 1 receptor alpha type 1, Interleukin 1 receptor antagonist protein (IRAP), rabbit IL-1 Receptor Antagonist, rabbit 1 receptor antagonist protein, rabbit IRAP, IL1F3, IL1RA, ICIL-1RA, IL1 inhibitor, INN: Anakinra, IL-1ra, IL-1RN, Interleukin-1 receptor antagonist protein |
| Gene, Accession # | UniProt: P18510 |
| Catalog # | orb420290 |
| Price | $292 |
| Order / More Info | IL-1 Receptor Antagonist Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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