Major Vault Protein / MVP Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Major Vault Protein / MVP antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | Major Vault Protein / MVP |
| Clone | r1032 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for > 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. |
| Immunogen | Proteins precipitated from human breast cancer MCF-7 cells were used as the immunogen for the recombinant MVP antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q14764 |
| Catalog # | orb1825368 |
| Price | $405 |
| Order / More Info | Major Vault Protein / MVP Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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