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Antigenic Specificity | GCLM / Glutamate-Cysteine Ligase Regulatory Subunit |
Clone | GCLM/4068 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | unconjugated |
Size | 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | g-glutamylcysteine synthetase (g-GCS) is the rate limiting enzyme for glutathione (L-g-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. g-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human g-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human g-GCS gene encoding the regulatory subunit maps to chromosome 1p22.1. The two subunits of g-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond. |
Immunogen | Recombinant full-length human GCLM protein was used as the immunogen for the GCLM antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P48507 |
Catalog # | orb1824613 |
Price | $764 |
Order / More Info | GCLM / Glutamate-Cysteine Ligase Regulatory Subunit Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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