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Antigenic Specificity | Integrin beta 3 / ITGB3 / CD61 |
Clone | ITGB3/2166R |
Host Species | Recombinant Rabbit |
Reactive Species | human |
Isotype | IgG, kappa |
Format | Protein A purified |
Size | 20 ug, 100 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with human Integrin beta 3, also called CD61. It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alpha-IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia. |
Immunogen | Human recombinant protein was used as the immunogen for the recombinant Integrin beta 3 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P05106 |
Catalog # | orb606399 |
Price | $405 |
Order / More Info | Integrin beta 3 / ITGB3 / CD61 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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