CD137 / 4-1BB / TNFRSF9 Antibody from BIORBYT LTD.
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| Antigenic Specificity | CD137 / 4-1BB / TNFRSF9 |
| Clone | LOB12 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | FACS, Functional Studies, IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors. |
| Immunogen | A murine CD137 human Fc fusion protein was used as the immunogen for the CD137 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P20334 |
| Catalog # | orb640143 |
| Price | $764 |
| Order / More Info | CD137 / 4-1BB / TNFRSF9 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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