MUC1 / Mucin-1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | MUC1 / Mucin-1 |
| Clone | MUC1/2818R |
| Host Species | Recombinant Rabbit |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | Protein A purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | ELISA, IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in > 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to MUC1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver. |
| Immunogen | Human milk fat globule membranes were used as the immunogen for this recombinant Mucin-1 antibody. |
| Other Names | n/a |
| Gene, Accession # | Gene ID: 4582, UniProt: P15941 |
| Catalog # | orb606814 |
| Price | $405 |
| Order / More Info | MUC1 / Mucin-1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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