FZD8 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | FZD8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to FZD8.Frizzled-8 (FZD8) is a receptor for Wnt proteins, which belongs to the G-protein coupled receptorFz/Smo family. FZD8 is a component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-cateninsignaling through inducing aggregation of receptor-ligand complexes into ribosome-sizedsignalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveledproteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt targetgenes. A second signaling pathway involving PKC and calcium fluxes has been seen for some familymembers. FZD8 may be involved in transduction and intercellular transmission of polarity informationduring tissue morphogenesis and/or in differentiated tissues. |
| Immunogen | middle region of human FZD8 |
| Other Names | FZD8,Frizzled8,Fz8,hFz8 |
| Gene, Accession # | UniProt: Q9H461 |
| Catalog # | orb67040 |
| Price | $527 |
| Order / More Info | FZD8 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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