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Antigenic Specificity | ACTN2 / Alpha Actinin 2 / Sarcomeric Alpha Actinin |
Clone | rACTN2/8177 |
Host Species | Recombinant Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 20 ug |
Concentration | n/a |
Applications | IHC-P, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. |
Immunogen | A portin of amino acids 557-692 from the human protein was used as the immunogen for the ACTN2 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P35609 |
Catalog # | orb1824162 |
Price | $405 |
Order / More Info | ACTN2 / Alpha Actinin 2 / Sarcomeric Alpha Actinin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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