Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Antibody from BIORBYT LTD.

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Antigenic SpecificityPhospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatunconjugated
Size100 ul
Concentrationn/a
ApplicationsELISA, IHC
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DescriptionThe M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240
Other NamesKCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me
Gene, Accession #Gene ID: 3786, UniProt: Q9NR82
Catalog #orb1730631
Price$296
Order / More InfoPhospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Antibody from BIORBYT LTD.
Product Specific Referencesn/a
BIORBYT LTD.
BIORBYT LTD.
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