MPZ / Myelin Protein Zero Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-MPZ / Myelin Protein Zero antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | MPZ / Myelin Protein Zero |
| Clone | MPZ/7390 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS. |
| Immunogen | Recombinant full-length human MPZ protein was used as the immunogen for the MPZ antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P25189 |
| Catalog # | orb1824339 |
| Price | $405 |
| Order / More Info | MPZ / Myelin Protein Zero Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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