CTNNB1 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-CTNNB1 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | CTNNB1 |
| Clone | RB41157 |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 400 ul, 80 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to CTNNB1. Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. |
| Immunogen | Synthetic Peptide |
| Other Names | CTNNB1, CTNNB, Catenin beta-1, Catenin beta-1, Beta-catenin |
| Gene, Accession # | UniProt: P35222 |
| Catalog # | orb106921 |
| Price | $561 |
| Order / More Info | CTNNB1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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