NRF1 / Nuclear Respiratory Factor 1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | NRF1 / Nuclear Respiratory Factor 1 |
| Clone | NRF1/2608 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes. |
| Immunogen | A recombinant full-length human protein was used as the immunogen for this NRF1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q16656 |
| Catalog # | orb639835 |
| Price | $405 |
| Order / More Info | NRF1 / Nuclear Respiratory Factor 1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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