DBC2 / RHOBTB2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | DBC2 / RHOBTB2 |
| Clone | DBC2/3362 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2c, lambda |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis. |
| Immunogen | A portion of amino acids 554-604 from the human protein was used as the immunogen for the DBC2 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q9BYZ6 |
| Catalog # | orb699649 |
| Price | $764 |
| Order / More Info | DBC2 / RHOBTB2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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