IL-3 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | IL-3 |
| Clone | IL3/4003 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Alpha subunit and a signal transducing beta subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the beta subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b. |
| Immunogen | A recombinant fragment of human Interleukin 3 protein was used as the immunogen for the IL-3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P08700 |
| Catalog # | orb1823334 |
| Price | $405 |
| Order / More Info | IL-3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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