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Antigenic Specificity | CD100 |
Clone | 133-1C6 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgM |
Format | fluorescein (FITC) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | FC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD100, also known as semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients. |
Immunogen | PHA stimulated human PBL |
Other Names | COLL4, SEMA4D, semaphorin 4D |
Gene, Accession # | Gene ID: 10507, UniProt: Q92854 |
Catalog # | orb1570908 |
Price | $372 |
Order / More Info | CD100 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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