IL-18 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-IL-18 antibody, protein, ELISA kits.
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| Antigenic Specificity | IL-18 |
| Clone | IL18/4622 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Alpha, IL-1beta and IL-1gamma/IL-18 and a specific receptor antagonist, IL-1RAlpha. IL-1Alpha and IL-1beta play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1gamma) has been shown to augment the secretion of IFN-gamma from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Alpha and IL-1beta respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1beta pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-gamma-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS). |
| Immunogen | A recombinant partial protein (within amino acids 1-193) from the human protein was used as the immunogen for the IL-18 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q14116 |
| Catalog # | orb1825985 |
| Price | $764 |
| Order / More Info | IL-18 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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