CTLA-4 / CD152 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-CTLA-4 / CD152 antibody, protein, ELISA kits.
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| Antigenic Specificity | CTLA-4 / CD152 |
| Clone | L4P2F5.F10 |
| Host Species | Mouse |
| Reactive Species | mouse, rat |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This CTLA4 antibody is specific to the soluble form of the protein. CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. |
| Immunogen | Amino acids CENAPNRARM were used as the immunogen for the CTLA4 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P16410 |
| Catalog # | orb639605 |
| Price | $764 |
| Order / More Info | CTLA-4 / CD152 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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