Alpha 1 microglobulin / AMBP / Bikunin Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Alpha 1 microglobulin / AMBP / Bikunin antibody, protein, ELISA kits.
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| Antigenic Specificity | Alpha 1 microglobulin / AMBP / Bikunin |
| Clone | AMBP/4536 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The AMBP (Alpha-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor, known as AMBP, that is cleaved to produce two distinct proteins, designated Alpha-1-Microglobulin and Bikunin. Alpha-1-Microglobulin, also known as protein HC, is a member of the lipocalin superfamily and is secreted mainly in plasma, urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity, Alpha-1-Microglobulin exhibits immunosuppressive properties, such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation, and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product, designated Bikunin and also known as inter-Alpha-trypsin inhibitor light chain, ITI-LC or urinary trypsin inhibitor, is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family, Bikunin prevents autodigestion by exocrine enzymes, such as trypsinogen and chymo-trypsinogen, and plays a role in the antiinflammatory/antiproteinase immune response. Unlike Alpha-1-Microglobulin, Bikunin is implicated in the pathogenesis of a number of renal diseases, such as urolithiasis. |
| Immunogen | A recombinant partial protein sequence (within amino acids 200-353) from the human protein was used as the immunogen for the Alpha 1 Microglobulin antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P02760 |
| Catalog # | orb1822716 |
| Price | $405 |
| Order / More Info | Alpha 1 microglobulin / AMBP / Bikunin Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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