IL1 beta / IL1B Antibody from BIORBYT LTD.
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| Antigenic Specificity | IL1 beta / IL1B |
| Clone | IL1B/4650 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | ELISA, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of mAb IL1B/463 and IL1B/4650 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
| Immunogen | A recombinant partial protein sequence (within amino acids 100-269) from the human protein was used as the immunogen for the Interleukin-1 beta antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01584 |
| Catalog # | orb1823861 |
| Price | $764 |
| Order / More Info | IL1 beta / IL1B Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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