p57 / p57Kip2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | p57 / p57Kip2 |
| Clone | KIP2/7187 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control. |
| Immunogen | Recombinant full-length human p57Kip2 protein was used as the immunogen for the p57Kip2 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P49918 |
| Catalog # | orb1826109 |
| Price | $405 |
| Order / More Info | p57 / p57Kip2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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