CDw17 (Lactosylceramide) Antibody from BIORBYT LTD.
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| Antigenic Specificity | CDw17 (Lactosylceramide) |
| Clone | HO18.3G-6.F5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgM, kappa |
| Format | PEG purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | FACS, IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. TNFa-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization. |
| Immunogen | Beta-2 Microglobulin associated proteins from a detergent lysate of human PBLs were used as the immunogen for the CDw17 antibody. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | orb749969 |
| Price | $764 |
| Order / More Info | CDw17 (Lactosylceramide) Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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