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Antigenic Specificity | Beta-2 Microglobulin |
Clone | BBM.1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | FACS, IHC-Fr, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 12kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha- heavy chain that contains three subdomains (alpha-1, alpha-2, alpha-3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha-3 subdomain of the alpha- heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha-1 and alpha-2 domains of the alpha- heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. |
Immunogen | MOLT-4 human T cell line was used as the immunogen for the Beta-2 Microglobulin antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P61769 |
Catalog # | orb749754 |
Price | $764 |
Order / More Info | Beta-2 Microglobulin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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