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Antigenic Specificity | CD79a |
Clone | ZL7.4 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | ELISA, FC, ICC, IHC-P, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
Immunogen | IgM complex isolated from Daudi cells |
Other Names | BCR alpha, Ig-alpha, MB-1, IGA |
Gene, Accession # | Gene ID: 973, UniProt: P11912 |
Catalog # | orb1088504 |
Price | $304 |
Order / More Info | CD79a Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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