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Antigenic Specificity | CD74 |
Clone | rCLIP/8679 |
Host Species | Recombinant Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+). |
Immunogen | A recombinant fragment of human CD74 protein was used as the immunogen for the CD74 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P04233 |
Catalog # | orb1823283 |
Price | $405 |
Order / More Info | CD74 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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