EBI3 / Epstein-Barr virus induced 3 Antibody from BIORBYT LTD.
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| Antigenic Specificity | EBI3 / Epstein-Barr virus induced 3 |
| Clone | EBI3/8902 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | ELISA, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Epstein-Barr virus-induced gene 3 (Ebi3) is a widely expressed homolog to the interleukin IL-12 p40 subunit protein that forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to create a new cytokine (IL-27). IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. Interferon-b differentially regulates expression of the IL-12 family members p35, p40, p19 and Ebi3 in activated human dendritic cells. Ebi3 may function to antagonize IL-12 and to inhibit the development of a Th1 immune response. Ebi3 is strongly expressed in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the tumor cells. Research suggests that Ebi3 may be an additional component of the repertoire employed by Hodgkin and Reed-Sternberg cells to inhibit an effective anti-tumor or anti-viral immune response. The human Ebi3 gene maps to chromosome 19p13.3 and encodes a secreted glycoprotein that is expressed in spleen and tonsils, and at high levels in full-term placenta. |
| Immunogen | A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the EBI3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q14213 |
| Catalog # | orb1824783 |
| Price | $405 |
| Order / More Info | EBI3 / Epstein-Barr virus induced 3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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