TCF7 / Transcription Factor 7 Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | TCF7 / Transcription Factor 7 |
| Clone | TCF7/7631 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. |
| Immunogen | A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the TCF7 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P36402 |
| Catalog # | orb1823337 |
| Price | $405 |
| Order / More Info | TCF7 / Transcription Factor 7 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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