LILRB1 / ILT-2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | LILRB1 / ILT-2 |
| Clone | VMP55 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | FACS, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. Immunoglobulin-like transcript 2 (ILT-2), also known as CD85 or MIR7, is a 650 amino acid glycoprotein that contains a 23 amino acid signal peptide, 4 extracellular C2-type IGSF domains and 4 intracellular ITIM motifs. ILT-2 can bind major histocompatability (MHC) class I molecules and inhibit cell termination by natural killer (NK) and T cells, and inhibit Ca2+ mobilization in myeloid cells triggered through the B cell antigen receptor and histocompatibility leukocyte antigens (HLA)-DR. ILT-2 contains four putative cytoplasmic tyrosine-based inhibitory motifs and upon tyrosine phosphorylation, associates with the tyrosine phosphatase SHP-1. |
| Immunogen | Hairy cell leukemia cells were used as the immunogen for the LILRB1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q8NHL6 |
| Catalog # | orb699629 |
| Price | $405 |
| Order / More Info | LILRB1 / ILT-2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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