Smad2/3 Antibody from BIORBYT LTD.
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| Edit | |
|---|---|
| Antigenic Specificity | Smad2/3 |
| Clone | 6H7 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG |
| Format | unconjugated |
| Size | 100 ul |
| Concentration | 1mg/ml |
| Applications | IHC, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 . Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses . |
| Immunogen | Recombinant Protein of Smad3 |
| Other Names | SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3 |
| Gene, Accession # | Gene ID: 4088, 4087, UniProt: Q15796 |
| Catalog # | orb1732677 |
| Price | $345 |
| Order / More Info | Smad2/3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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