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Antigenic Specificity | HP1 gamma |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | IgG |
Format | unconjugated |
Size | 100 ul |
Concentration | 1mg/ml |
Applications | IHC, IP, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. |
Immunogen | A synthetic peptide of mouse HP1 gamma |
Other Names | HECH; HP1-GAMMA; HP1Hs-gamma; CBX3 |
Gene, Accession # | Gene ID: 12417, UniProt: P23198 |
Catalog # | orb1731844 |
Price | $345 |
Order / More Info | HP1 gamma Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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