HP1 gamma Antibody from BIORBYT LTD.

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Antigenic SpecificityHP1 gamma
Clonemonoclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
IsotypeIgG
Formatunconjugated
Size100 ul
Concentration1mg/ml
ApplicationsIHC, IP, WB
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DescriptionComponent of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
ImmunogenA synthetic peptide of mouse HP1 gamma
Other NamesHECH; HP1-GAMMA; HP1Hs-gamma; CBX3
Gene, Accession #Gene ID: 12417, UniProt: P23198
Catalog #orb1731844
Price$345
Order / More InfoHP1 gamma Antibody from BIORBYT LTD.
Product Specific Referencesn/a
BIORBYT LTD.
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240

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