KDEL Receptor Antibody from BIORBYT LTD.
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| Antigenic Specificity | KDEL Receptor |
| Clone | KR-10 |
| Host Species | Mouse |
| Reactive Species | bovine, canine, Drosophila, frog, chicken, hamster, human, monkey, mouse, porcine, rabbit, rat, sheep |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | ICC, IHC, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mouse monoclonal to KDEL R (Biotin). The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention. There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity; and all are located within the cis-Golgi and its intermediate compartments. In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding. It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal. |
| Immunogen | A 21 residue synthetic peptide (amino acids 192-212) based on the bovine KDEL receptor and the peptide coupled to KLH |
| Other Names | ERD2, ERD2.1, ERD21, HDEL, KDEL, KDEL R1, KDELR1, PM23 |
| Gene, Accession # | Gene ID: 618184, UniProt: P33946 |
| Catalog # | orb147075 |
| Price | $545 |
| Order / More Info | KDEL Receptor Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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