DBC1 / Deleted in breast cancer 1 / CCAR2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | DBC1 / Deleted in breast cancer 1 / CCAR2 |
| Clone | PCRP-KIAA1967-1D10 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | FACS, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein and Cell cycle and apoptosis regulator protein 2 (CCAR2), is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF-Alpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-Alpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER-Alpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth. |
| Immunogen | Recombinant full-length human CCAR2 / KIAA1967 protein was used as the immunogen for the DBC1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q8N163 |
| Catalog # | orb1822896 |
| Price | $405 |
| Order / More Info | DBC1 / Deleted in breast cancer 1 / CCAR2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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