Cav1.2 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Cav1.2 |
| Clone | S57 |
| Host Species | Mouse |
| Reactive Species | hamster, human, mouse, rat |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | AM, ICC, IHC, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mouse monoclonal to CaV1 (Biotin). 2. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on an ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, Cav1. 2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy's syndrome and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well.... |
| Immunogen | Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 |
| Other Names | CACH3, CACN4, CACNA 1D, CACNL1A2, voltage dependent L type calcium channel subunit alpha 1D, alpha-1 subunit voltage-dependent calcium channel, calcium channel voltage-dependent L type alpha 1C subunit1, voltage-gated calcium channel alpha subunit Cav1.2, calcium channel L type, alpha 1 polypeptide isoform 1 cardic muscle, calcium channel cardic dihydropyridine-sensitive alpha-1 subunit, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10, DHPR alpha-1 subunit, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle |
| Gene, Accession # | Gene ID: 100101555, UniProt: P15381 |
| Catalog # | orb148161 |
| Price | $567 |
| Order / More Info | Cav1.2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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