Caspase-3 , Pro and Active Antibody from BIORBYT LTD.
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| Antigenic Specificity | Caspase-3 , Pro and Active |
| Clone | CAS3836 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 100 ug, 25 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the 'executioners of apoptosis.' Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 ('initiator caspases') and then effects apoptosis by cleaving targeted cellular proteins. |
| Immunogen | The large subunit domain of human Caspase-3 was used as the immunogen for this monoclonal antibody. |
| Other Names | n/a |
| Gene, Accession # | Gene ID: 836 |
| Catalog # | orb248113 |
| Price | $643 |
| Order / More Info | Caspase-3 , Pro and Active Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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