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Antigenic Specificity | Alpha Catenin |
Clone | 1G5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | FACS, IF, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer. |
Immunogen | A human fusion protein was used as the immunogen for the Alpha Catenin antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P35221 |
Catalog # | orb385946 |
Price | $764 |
Order / More Info | Alpha Catenin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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