Nectin-4 / PVRL4 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Nectin-4 / PVRL4 |
| Clone | NECT4/7271 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta. |
| Immunogen | A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q96NY8 |
| Catalog # | orb1716143 |
| Price | $405 |
| Order / More Info | Nectin-4 / PVRL4 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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