Lambda Light Chain Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Lambda Light Chain antibody, protein, ELISA kits.
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| Antigenic Specificity | Lambda Light Chain |
| Clone | N10/2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | FACS, IF, IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 3:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm.Individual B-cells in lymphoid tissue possess either kappa or lambda light chains, but never both together. Specific rearrangement of lambda light chain of immunoglobulins can lead to loss of some protein coding genes, which does not seem to be functionally relevant (while functionally relevant miR-650 can be overexpressed). Using immunohistochemistry, it is possible to determine the relative abundance of B-cells expressing kappa and lambda light chains. If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma. [Wiki] |
| Immunogen | IgG purified from human serum was used as the immunogen for this Lambda Light Chain antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01701 |
| Catalog # | orb386002 |
| Price | $764 |
| Order / More Info | Lambda Light Chain Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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