IL1 alpha / IL1A Antibody from BIORBYT LTD.
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| Antigenic Specificity | IL1 alpha / IL1A |
| Clone | IL1A/3981 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Two forms of interleukin-1, designated IL-1 alpha and beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. |
| Immunogen | A portion of amino acids 113-271 from the human protein was used as the immunogen for the IL1A antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01583 |
| Catalog # | orb699766 |
| Price | $405 |
| Order / More Info | IL1 alpha / IL1A Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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