TNF alpha Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-TNF alpha antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | TNF alpha |
| Clone | P/T2 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgM, kappa |
| Format | PEG purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | FACS, IF, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. |
| Immunogen | Amino acids 115-130 (NGVELRDNQLVVPSEG) from the human protein were used as the immunogen for the TNF-a antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01375 |
| Catalog # | orb749821 |
| Price | $405 |
| Order / More Info | TNF alpha Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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