Cyclin D1 / CCND1 Antibody from BIORBYT LTD.

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Antigenic SpecificityCyclin D1 / CCND1
CloneBCLD1-1
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a, kappa
FormatProtein G purified
Size100 ug, 20 ug
Concentrationn/a
ApplicationsFACS, IHC-P
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DescriptionRecognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
ImmunogenRecombinant human protein was used as the immunogen for the Cyclin D1 antibody.
Other Namesn/a
Gene, Accession #UniProt: P24385
Catalog #orb385804
Price$764
Order / More InfoCyclin D1 / CCND1 Antibody from BIORBYT LTD.
Product Specific Referencesn/a
BIORBYT LTD.
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240

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