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Antigenic Specificity | SHANK2 |
Clone | N23b/6 (Formerly sold as S23b-6) |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | ATTO-594 conjugate |
Size | 100 ug |
Concentration | 1 mg/ml |
Applications | AM, ICC, IHC, IP, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse monoclonal to SHANK2 (ATTO-594). Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimers disease.. |
Immunogen | Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2) |
Other Names | Shank2, PROSAP1, cortactin binding protein 1, KIAA1022, AUTS17, CortBP1, Proline-rich synapse-associated protein 1, SH3 and multiple ankyrin repeat domains protein 2, Cortactin-binding protein 1, proline-rich synapse associated protein 1, SPANK-3, GKAP/SAPAP interacting protein, SHANK, cortactin SH3 domain-binding protein, ProSAP1, CORTBP1CTTNBP1, SH3 and multiple ankyrin repeat domains 2 |
Gene, Accession # | Gene ID: 171093, UniProt: Q9QX74 |
Catalog # | orb148596 |
Price | $573 |
Order / More Info | SHANK2 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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