A2M / Alpha-2-Macroglobulin Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-A2M / Alpha-2-Macroglobulin antibody, protein, ELISA kits.
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| Antigenic Specificity | A2M / Alpha-2-Macroglobulin |
| Clone | A2M/6555 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Alpha-2-Macroglobulin (Alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, Alpha-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on Alpha-2M. This interaction induces a conformational change in Alpha-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, Alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serum is primarily bound to Alpha-2M, which renders TGFbeta inactive. Alpha-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding Alpha-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of Alpha-2M in mediating the clearance and degradation of A beta, the major component of beta-Amyloid deposits accumulated during AD. |
| Immunogen | A recombinant partial protein sequence (within amino acids 600-800) from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P01023 |
| Catalog # | orb1825800 |
| Price | $405 |
| Order / More Info | A2M / Alpha-2-Macroglobulin Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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