MerTK Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-MerTK antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | MerTK |
| Clone | MERTK/3015 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells. |
| Immunogen | A recombinant human partial protein (amino acids 55-148) was used as the immunogen for the MerTK antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q12866 |
| Catalog # | orb639575 |
| Price | $764 |
| Order / More Info | MerTK Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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