Thymidine Phosphorylase / PD-ECGF Antibody from BIORBYT LTD.
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| Antigenic Specificity | Thymidine Phosphorylase / PD-ECGF |
| Clone | rTYMP/3444 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites. |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the recombinant PD-ECGF antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P19971 |
| Catalog # | orb699607 |
| Price | $405 |
| Order / More Info | Thymidine Phosphorylase / PD-ECGF Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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