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Antigenic Specificity | Prohibitin / PHB |
Clone | PHB/3229 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | IHC-P, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes a protein of 30kDa which is identified as Prohibitin (PHB), an evolutionarily conserved protein with homologues found in yeast to man. It is located in the inner membrane of mitochondria. Although PHB mRNA and protein expression occurs throughout the cell cycle, maximum levels are detected during the G1/S phase transition and minimum levels are seen in S phase and the G2/mitosis boundary. Prohibitin is located exclusively in the mitochondria with the highest concentration on the inner membrane. It is an ideal mitochondrial marker. It shows anti-proliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression. |
Immunogen | A recombinant human partial protein corresponding to amino acids 167-261 was used as the immunogen for the PHB antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P35232 |
Catalog # | orb607189 |
Price | $764 |
Order / More Info | Prohibitin / PHB Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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